Performance Analysis of FET-Based Nanoiosensors by Computational Method

Background

The following review briefly describes the progress of biosensing technology until now including both experimental and computational contributions.

Experimentally there are many literatures which address the development of various nanobiosensors which are based on diverse principles of detection and produce different types of devices. Nanoparticles, carbon nanotubes (CNTs), naowire, magnetic particles, metallic platelets and graphene sheets are some of the candidates found to be used for this purpose. Not only in nanomedicine, biosensors are used in finding food pathogens, environment pollutants and in bioterrorism. Lee and Fauchet (2007) Synthesized high sensitive plane photonic crystal micro cavity biosensor on silicon insulator wafer. The authors presented their method both theoretically and experimentally. This methodology is helpful to detect extremely little mass of the order 2.5fg by getting the resonance redshift from the binding of glutaraldehyde and bovine serum albumin. The sensor can measure the dehydrated protein, so it has a different importance in the field of biosensing. The well agreement between experimental data and theoretical results points towards the high performance of such sensor. By the improvement of Q factor and proper positioning of the biological molecule, quality of the sensor can be improved. Zhu, Du and Fu (2009) developed rhombic silver nanoparticles for the localized surface Plasmon resonance of biosensor. The detection is improved from the triangular particles to rhombic nanoparticles biosensor. By this method, one can sense the refractive index sensitivity till 330 nm with the help of Discrete Dipole Approximation by algorithm designed method. To diagnose the genetic diseases in early stage, it demands the detection of the opposite base pairs in DNA. The silicon nanowire FET biosensors have wide importance because of its capacity to detect protein established on frequency domain electrical measurement (Zheng, Gao & Leiber, 2010). The measurement of antibodies of silicon nanowire bisosensor is done with the help of frequency domain and power spectral density of voltage. The frequency and general time arena measured with this setup with antigen concentration given more detection sensitivity for the frequency domain. The present work confirms the measurements of frequency domain are free set about general time domain measurements which leads to finding the high sensitive electrical proteins.