Mitogaphy is a selective autophagic degradation of mitochondria, playing a crucial role in maintaining cellular homeostasis by eliminating damaged or dysfunctional mitochondria. Relating to cancer, mitophagy influences tumorigenesis, progression, and therapeutic response in complex and contradictory ways. By regulating mitochondrial quality control, energy metabolism, and apoptotic signaling, mitophagy contributes to the delicate balance between cell survival and death. This process can support cancer cell survival under stress conditions such as hypoxia and nutrient deprivation, yet it can suppress tumor development by limiting oxidative stress and genome instability. Understanding the multifaceted roles of mitophagy in cancer regulation is essential for developing targeted therapeutic strategies and improving clinical outcomes.
Roles of Mitophagy in Cancer Regulation explores how mitophagy influences cell differentiation and its central role in cellular activities. It examines how mitophagy is regulated in cancer, the removal of damaged mitochondria through autophagy, and the maintenance of proper cellular functions. Covering topics such as cellular biology, DNA, and mitochondrial science, this book is an excellent resource for engineers, medical professionals, academicians, scientists, and researchers.